Drugs That Can Cause False Positives in a Drug Test

Knowing what drugs can cause false positives ensures that you know to know to notify the testing lab and also can identify the reason for a false positive

Read more about drugs that cause false positives...

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Drugs That Can Cause False Positives in a Drug Test

Knowing what drugs can cause false positives ensures that you know to know to notify the testing lab and also can identify the reason for a false positive


If you take one of the following drugs, you should make it known before submitting a urine sample. It can be more difficult to prove your innocence after testing positive. Many people wrongly believe drug tests are infallible and you may not even get the chance to defend yourself. So it's better to prepare for a possible false positive in advance.

If you take any medications, you should research the drug to see if it is known to trigger false positives. Below are 14 legal drugs that are known to cause false positives.

1. Dextromethorphan

An active ingredient in cough medicines.

2. Diltiazem

Used as a treatment for hypertension.

3. Diphenhydramine

An antihistamine present in many allergy medications.

4. Metformin

A common diabetes medication

5. Pseudoephedrine

Used to treat sinus congestion.

6. Labetalol

An alpha and beta-blocker used to treat hypertension.

7. Methylphenidate

Used to treat ADHD.

8. Doxylamine

Found in many over-the-counter sleep aids.

9. Tramadol

A prescription pain medication.

10. Phentermine

A common weight loss drug.

11. NSAIDs

Found in common painkillers like Advil and Motrin.

12. Antidepressants

Many antidepressants are known to cause false positives.

13. Proton pump inhibitors

Used to treat gastrointestinal reflux.

14. Quinolone antibiotics

Used to treat urinary tract infections, sinus infections, and pneumonia, and more.

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